Anabel Sanchez

SJS can be caused by infections (usually following viral infections such as herpes simplex virus, influenza, mumps, cat-scratch fever, histoplasmosis, Epstein-Barr virus, or similar), allergic reactions to drugs, (Dicloflex, fluconazole, valdecoxib, penicillins, barbiturates, sulfas, phenytoin, lamotrigine, nevirapine, Ibuprofen, ethosuximide, carbamazepine), malignancy (carcinomas and lymphomas), or idiopathic factors (up to 50% of the time). SJS has also been consistently reported as an uncommon side effect of herbal supplements containing ginseng. SJS may also be caused by cocaine usage.

Although Stevens Johnson Syndrome may be caused by viral infections or malignancies, severe allergic reactions to medication is the leading cause. Medications that have traditionally been known to lead to Stevens Johnson Syndrome, Erythema Multiforme, Lyell's Syndrome, and Toxic Epidermal Necrolysis include sulfonamides (antibiotics), penicillins (antibiotics), barbiturates (sedatives), and phenytoin - Dilantin (anticonvulsant).